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KMID : 0869620200370040471
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Journal of Korean Society of Hospital Pharmacists
2020 Volume.37 No. 4 p.471 ~ p.484
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The Associations Between Liraglutide and Risk of Acute Pancreatitis in Patients with Type 2 Diabetes : A Meta-analysis
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Lee Young-Hoon
Park Jung-Kyu
Choi Hye-Duck
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Abstract
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Background : Acute pancreatitis is an important and serious disease even with a relatively low incidence. Also, previous studies suggest that the coexistence of Type 2 diabetes and acute pancreatitis is closely related to an increased risk of death. However, the risk of acute pancreatitis in patients treated with liraglutide, a GLP-1 receptor agonist, has not been adequately evaluated.
Objective : This meta-analysis was conducted to investigate the association between the liraglutide and acute pancreatitis in patients with Type 2 diabetes.
Methods : Forty-one studies were assessed, and the results of the included studies were quantitatively integrated using the meta-analysis. The incidence of the liraglutide-related acute pancreatitis was estimated. As a sub-group analysis, four studies were assessed for comparing the liraglutide-treated groups and the control groups (placebo or other antidiabetic drugs except GLP-1 receptor agonists).
Results : The incidence of acute pancreatitis was 0.4% (95% confidence interval (CI) 0.3%-0.5%). The risk of acute pancreatitis was not significantly different between the liraglutide-treated groups and the control groups (odds ratio=1.412; 95% CI 0.290-6.866).
Conclusion : The incidence of liraglutide-related acute pancreatitis was relatively low and not additionally increased compared to the other antidiabetic drugs. We suggest that this meta-analysis is meaningful as evidence for the clinical use of liraglutide.
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KEYWORD
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Liraglutide, Acute pancreatitis, Meta-analysis, Type 2 diabetes
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